Randomised controlled trials of complex interventions
نویسندگان
چکیده
منابع مشابه
Randomised controlled trials of complex interventions
Although all randomised controlled trials (RCT) share much in common in terms of design, conduct, analysis and reporting, trials of complex interventions (loosely “interventions with several interacting components”) can have special issues which need appropriate consideration to deliver high quality and credible evidence to change or inform practice. For example, blinding the intervention may b...
متن کاملProcess evaluation in randomised controlled trials of complex interventions.
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متن کاملMediation and moderation of treatment effects in randomised controlled trials of complex interventions.
Complex intervention trials should be able to answer both pragmatic and explanatory questions in order to test the theories motivating the intervention and help understand the underlying nature of the clinical problem being tested. Key to this is the estimation of direct effects of treatment and indirect effects acting through intermediate variables which are measured post-randomisation. Using ...
متن کاملUse of qualitative methods alongside randomised controlled trials of complex healthcare interventions: methodological study
OBJECTIVE To examine the use of qualitative approaches alongside randomised trials of complex healthcare interventions. DESIGN Review of randomised controlled trials of interventions to change professional practice or the organisation of care. DATA SOURCES Systematic sample of 100 trials published in English from the register of the Cochrane Effective Practice and Organisation of Care Revie...
متن کاملAnalysis and comment Health services research Process evaluation in randomised controlled trials of complex interventions
“Complex interventions” are health service interventions that are not drugs or surgical procedures, but have many potential “active ingredients.” A complex intervention combines different components in a whole that is more than the sum of its parts. Randomised controlled trials (RCTs) are the most rigorous way to evaluate the effectiveness of interventions, regardless of their complexity. Becau...
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ژورنال
عنوان ژورنال: Trials
سال: 2011
ISSN: 1745-6215
DOI: 10.1186/1745-6215-12-s1-a142